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No distinct dose adjustment recommended when tofacitinib coadministered with strong CYP2C19 inhibitors; reduce tofacitinib dose if coadministered with both equally reasonable CYP3A4 and powerful CYP2C19 inhibitors .modafinil will boost the degree or impact of rabeprazole by influencing hepatic enzyme CYP2C19 metabolism. Small/Significance Not known

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